Cissus Quadrangularis

Heralded far and wide for its countless benefits, cissus quadrangularis is one of the most powerful all-natural joint support supplements available. Cissus is rich in a type of plant sterol known as ketosterones. These phytochemicals are responsible for the numerous benefits of cissus supplementation. Machine Motion includes a premium-grade cissus extract standardized to 40% ketosterones.

Cissus supplementation has been well-documented to combat inflammation, relieve joint pain, and promote collagen synthesis.[1,2,3,4] This is all in addition to its ability to enhance weight loss and cholesterol levels.

Acumin™

Developed by Novel Ingredients, Acumin™ is a trademarked extract of curcumin supplying 45% curcuminoids. This one-of-a-kind complex has been clinically shown to offer 5-6x greater bioavailability than conventional curcumin supplements.[5]

Curcumin has long been used in folk medicine as a powerful, and all-natural, anti-inflammatory compound that combats both acute and chronic inflammation in the body. Curcumin accomplishes this via inhibition of Cytokine production and down-regulation of COX-2 activity, mimicking the effects of ibuprofen.[6,7]

Bromelain

Naturally-occurring in pineapple, bromelain is a digestive enzyme that also serves as an effective pain relief compound, too. Bromelain has been used for centuries an all-natural anti-inflammatory agent to reduce redness and swelling.[8] Furthermore, the versatile enzyme also has shown efficacy in treating the aches and pains induced by osteoarthritis.[9,10]

Sodium Hyaluronate

Sodium Hyaluronate is a highly bioavailable form of hyaluronic acid, a glycosaminoglycan present in connective tissue that lubricates and cushions your joints. Countless studies have shown the effectiveness of hyaluronic acid, with some dubbing it the “fountain of youth.” Treatment with hyaluronic acid can reduce joint pain, improve symptoms of osteoarthritis, and may even reduce the need for joint replacement.[11,12,13]

Q-Actin™

Machine Motion utilizes one of the newest, groundbreaking joint support supplements in Q-Actin, a patented, clinically-tested extract of cucumber. Research conducted on the novel extract demonstrates it significantly improves knee pain, stiffness, and physical function in patients suffering from osteoarthritis.[14] Doses used in the landmark study were 20mg, the exact same dose included in Machine Motion! Q-Actin is able to accomplish this by inhibit the production of TNF-?, tumor necrosis factor alpha, an inflammatory cytokine associated with a number of inflammatory diseases including osteoarthritis.[15,16] Reducing factors that promote inflammation promotes increased range of motion, decreased pain, and improved quality of life.

BioPerine®

All the joint support compounds won’t do a lick of good if you’re body isn’t able to utilize them. That’s where BioPerine® comes in. This industry-leading black pepper extract improves ingredient bioavailability, ensuring maximal uptake and utilization by the body. BioPerine inhibits various enzymes preserving ingredient integrity, certifying you get all the joint pain relief possible from each and every serving of Machine Motion.

1. Bloomer RJ, Farney TM, McCarthy CG, Lee S-R. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study. Phys Sportsmed. 2013;41(3):29-35. doi:10.3810/psm.2013.09.2021.
2. Ferrandiz, ML, and MJ Alcaraz. “Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids.” Agents and actions 32.3-4 (1991): 283-288.
3. Lin, J et al. “Preliminary screening of some traditional Zulu medicinal plants for anti-inflammatory and anti-microbial activities.” Journal of Ethnopharmacology 68.1 (1999): 267-274.
4. Muthusami S, et al. Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells. J Cell Biochem. (2011)
5. Nutrition TR. Acumin Ingredient Information. http://www.novelingredient.com/wp-content/uploads/2016/07/Acumin-Sell-Sheet.pdf.
6. Jurenka, J; Anti-inflammatory Properties of Curcumin, a Major Constituent of Curcuma longa: A Review of Preclinical and Clinical Research; Alt Med Rev; 2009
7. Kumar, A., Takada, Y., Borief, A., Aggarwa, B.; Nuclear factor KappaB: its role in health and disease; J Mol, Med; 2004
> 8. Zatuchni GI, Colombi DJ. Bromelains therapy for the prevention of episiotomy pain. Obstet Gynecol. 1967 Feb;29(2):275-8.
9. Brien S, Lewith G, Walker AF, Middleton R, Prescott P, Bundy R. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM. 2006 Dec;99(12):841-50.
10. Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004 Dec;1(3):251-257. Epub 2004 Oct 6.
11. Kotz, R.; Kolarz, G. (1999). "Intra-articular hyaluronic acid: Duration of effect and results of repeated treatment cycles". American journal of orthopedics (Belle Mead, N.J.). 28 (11 Suppl): 5–7. PMID 10587245
12. Bannuru, R. R.; Natov, N. S.; Dasi, U. R.; Schmid, C. H.; McAlindon, T. E. (2011). "Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis – meta-analysis". Osteoarthritis and Cartilage. 19 (6): 611–619. doi:10.1016/j.joca.2010.09.014. PMID 21443958.
13. Salk, R. S.; Chang, T. J.; d'Costa, W. F.; Soomekh, D. J.; Grogan, K. A. (2006). "Sodium Hyaluronate in the Treatment of Osteoarthritis of the Ankle: A Controlled, Randomized, Double-Blind Pilot Study". The Journal of Bone and Joint Surgery. 88 (2): 295–302.
14. Nash R, EFFECTIVENESS OF Cucumis sativus EXTRACT (CSE) VERSUS GLUCOSAMINE-CHONDROITIN (GC) IN THE MANAGEMENT OF OSTEOARTHRITIS: A RANDOMIZED CONTROL TRIAL. J Gerontol Geriatr Res. 2017;6(3):7182.
15. Mabey T, Honsawek S. Cytokines as biochemical markers for knee osteoarthritis. World Journal of Orthopedics. 2015;6(1):95-105. doi:10.5312/wjo.v6.i1.95
16. Google Books. (2018). Patent WO2015150966A1 - Food supplement composition comprising a cucumber (cucumis sativus) extract.